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Intravenous Ceftriaxone for Syphilitic Uveitis.

Fernanda A Agostini1,2, Rafael P Queiroz1,3,4, Danuza O M Azevedo1

  • 1a Uveitis Unit, Hospital São Geraldo / Hospital das Clínicas da Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.

Ocular Immunology and Inflammation
|May 9, 2017
PubMed
Summary
This summary is machine-generated.

Intravenous ceftriaxone offers an effective alternative treatment for syphilitic uveitis when penicillin G is unavailable. This study shows significant improvement in ocular inflammation and visual acuity in patients treated with ceftriaxone.

Keywords:
Ceftriaxonemultimodal imagingneurosyphilissyphilisuveitis

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Pharmacology

Background:

  • Syphilitic uveitis is a serious ocular condition requiring effective treatment.
  • Penicillin G is the standard treatment, but its unavailability necessitates alternative therapeutic options.

Purpose of the Study:

  • To evaluate the clinical and multimodal imaging outcomes of patients with syphilitic uveitis treated with intravenous (IV) ceftriaxone.
  • To assess the efficacy of IV ceftriaxone as an alternative treatment for syphilitic uveitis.

Main Methods:

  • A chart review was conducted for patients diagnosed with syphilitic uveitis between January and August 2014.
  • Data collected included clinical, serological, and ophthalmological findings for patients treated with IV ceftriaxone.

Main Results:

  • Twelve patients with syphilitic uveitis received IV ceftriaxone (2-4 g daily) for 14-21 days.
  • All 24 affected eyes showed improvement in intraocular inflammation.
  • Median best-corrected visual acuity improved from 20/50 to 20/20 after a mean follow-up of 5.3 months.

Conclusions:

  • Intravenous ceftriaxone demonstrates potential as an effective alternative treatment for syphilitic uveitis.
  • This finding is particularly relevant in situations where penicillin G is not accessible.