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Clotting during autologous hematopoietic progenitor cells collection
Amit Gokhale1,2, NurJehan Quraishy1, Viva Veemara3
1Section of Transfusion Medicine, Cleveland Clinic, Cleveland, Ohio.
Hematopoietic progenitor cell (HPC) collection via leukapheresis can clot if anticoagulation is inadequate, even without machine alarms. This case highlights a potential risk during standard HPC transplant procedures.
Area of Science:
- Hematology
- Transplantation Medicine
- Apheresis Technology
Background:
- Autologous hematopoietic progenitor cell (HPC) transplantation using peripheral blood mobilization and leukapheresis is a standard oncologic therapy.
- Leukapheresis procedures are generally safe but can be associated with complications.
- Clotting during apheresis is a known, albeit infrequent, complication.
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