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Implementation of a Nonlinear Microscope Based on Stimulated Raman Scattering

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Robust numerical phase stabilization for long-range swept-source optical coherence tomography.

Shaozhen Song¹, Jingjiang Xu¹, Shaojie Men¹

¹University of Washington, Department of Bioengineering, Seattle, WA 98195, USA.

Journal of Biophotonics

|May 10, 2017

Summary

This summary is machine-generated.

A new numerical method enhances phase stability in swept-source optical coherence tomography (SS-OCT) systems using MEMS-VCSELs. This technique improves imaging in scattering tissues without hardware changes, boosting contrast-to-noise ratio and depth range.

Keywords:

optical coherence tomography phase-sensitive measurement swept laser

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Area of Science:

Biomedical Optics
Optical Engineering
Medical Imaging

Background:

Swept-source optical coherence tomography (SS-OCT) systems face challenges with phase stability, impacting image quality.
Micro-electromechanical (MEMS) vertical cavity surface-emitting lasers (VCSELs) are crucial components in advanced SS-OCT systems.
Existing phase stabilization methods often require hardware modifications or significant computational resources.

Purpose of the Study:

To introduce and validate a novel, fully numerical phase stabilization technique for MEMS-VCSEL based SS-OCT.
To assess the technique's performance in terms of phase stability, accuracy, and computational efficiency.
To demonstrate the technique's applicability to complex imaging modalities like OCT angiography (OCTA).

Main Methods:

Implementation of a fully numerical phase stabilization algorithm without hardware alterations.
Testing the technique on biological tissue samples with varying scattering properties.
Comparative analysis of the proposed method against conventional numerical approaches.
Application to optical coherence tomography angiography (OCTA) and Doppler OCTA.

Main Results:

Achieved a phase sensitivity of 89 mrad in highly scattering tissue.
Enabled imaging with a range distance of up to 12.5 mm at a 100.3 kHz A-line scan rate.
Demonstrated significant improvements in image contrast-to-noise ratio and extended OCTA depth range.
Showcased high tolerance to acquisition jitter and reduced computational load.

Conclusions:

The proposed numerical phase stabilization technique offers a robust and efficient solution for enhancing SS-OCT performance.
The method is universally applicable to various SS-OCT systems and scan rates without hardware modifications.
This advancement has the potential to significantly improve diagnostic capabilities in biomedical imaging.