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Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
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Developing organ-on-a-chip concepts using bio-mechatronic design methodology.

Jonas Christoffersson1, Danny van Noort, Carl-Fredrik Mandenius

  • 1Division of Biotechnology, IFM, Linköping University, SE-581 83 Linköping, Sweden.

Biofabrication
|May 10, 2017
PubMed
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Bio-mechatronic design integrates biology, mechanics, and electronics for advanced organ-on-a-chip devices. This systematic approach optimizes the design and fabrication of in vitro cell culture systems to meet user needs.

Area of Science:

  • Biomedical Engineering
  • Systems Engineering

Background:

  • Mechatronic design is a user-centric engineering methodology.
  • Organ-on-a-chip (OOC) devices require integrating biological, mechanical, and electronic components.

Purpose of the Study:

  • To introduce and apply the bio-mechatronic design methodology to OOC devices.
  • To highlight the integration of biology, mechanics, and electronics in OOC design.
  • To demonstrate how this approach can optimize OOC development.

Main Methods:

  • Exploiting mechatronic design principles for in vitro cell cultures.
  • Introducing the term 'bio-mechatronic design' to address the interdisciplinary complexity.
  • Systematically evaluating functional design alternatives based on user needs and specified criteria.

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  • Applying the methodology to a liver-on-a-chip model.

    • Main Results:

    • The bio-mechatronic design methodology provides a systematic framework for OOC development.
    • It facilitates the integration of biological, mechanical, and electronic elements.
    • The approach generated novel fabrication solutions and design refinement guidelines for OOC devices.
    • Demonstrated successful application to a liver-on-a-chip system.

    Conclusions:

    • Bio-mechatronic design offers a powerful methodology for advancing OOC technology.
    • This approach enhances the systematic design and fabrication of complex biological devices.
    • It provides a structured pathway for optimizing OOC devices for specific applications and user requirements.