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Related Experiment Video

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Neocortical activity is stimulus- and scale-invariant.

Yahya Karimipanah1, Zhengyu Ma1, Jae-Eun Kang Miller2

  • 1Department of Physics, Washington University, St. Louis, Missouri, United States.

Plos One
|May 11, 2017
PubMed
Summary

The brain

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • The cerebral cortex is hypothesized to operate near a critical state, a balance between order and disorder.
  • This critical state is characterized by neuronal avalanches with power-law distributions in size and duration.
  • Previous research confirmed neuronal avalanches in vitro and in vivo across species and scales.

Purpose of the Study:

  • To investigate how external visual stimulation affects the scale-free properties of cortical activity.
  • To determine if neuronal avalanche characteristics change with varying sensory inputs.
  • To understand the dynamic functional connectivity of the visual cortex during stimulation.

Main Methods:

  • In vivo two-photon population calcium imaging of layer 2/3 neurons in the primary visual cortex of behaving mice.

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  • Statistical analysis of inferred spike trains to identify neuronal avalanches.
  • Comparison of avalanche properties and spike train characteristics under different visual stimuli.

    • Main Results:

    • Neuronal avalanches with power-law distributions were consistently observed.
    • Individual neuron spiking patterns were irregular.
    • Avalanche and spike train properties remained stable across different visual stimuli.
    • Stimulus-dependent variations were observed in the cross-correlation structure of neural activity.

    Conclusions:

    • Visual cortex microcircuits operate near the critical regime.
    • Cortical activity exhibits scale-free properties that are robust to external stimulation.
    • Functional connectivity rearranges in response to varying sensory inputs, adapting to the environment.