Related Experiment Video
Updated: Mar 2, 2026

EEG Mu Rhythm in Typical and Atypical Development
Published on: April 9, 2014
Theta Rhythmopathy as a Cause of Cognitive Disability in TLE
Tristan Shuman1, Benjamin Amendolara1,2,3, Peyman Golshani1,4,5,6
1Departments of Neurology and Psychiatry, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA.
Abstract:
Memory difficulties are commonly associated with temporal lobe epilepsy (TLE) and cause significant disability. This article reviews the role of altered hippocampal theta oscillations and theta-gamma coupling as potential causes of memory disturbance in temporal lobe epilepsy, dissecting the potential mechanisms underlying these changes in large-scale neuronal synchronization. We discuss development of treatments for cognitive dysfunction directed at restoring theta rhythmicity and future directions for research.

