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Published on: June 13, 2022
Biomimetic Total Synthesis of (±)-Homodimericin A
Donghui Ma1, Yangbin Liu1, Zhang Wang1
1Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave. CH232, Albany, NY, 12222, USA.
Abstract:
A biomimetic total synthesis of racemic homodimericin A was achieved in seven steps, including two cascade reactions. Aqueous buffer solutions are found to help both the oxidative dimerization cascade and the intramolecular Diels-Alder cascade. This synthetic sequence validates key steps in the biogenetic proposal of homodimericin A.
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