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Updated: Mar 2, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Triazaspirocycles: Occurrence, Synthesis, and Applications
Claire M Gober1, Patrick J Carroll1, Madeleine M Joullié1
1Department of Chemistry, University of Pennsylvania, Philadelphia, PA, United States of America.
Abstract:
Natural products bearing a triazaspirocyclic motif have received significant attention in recent years. These compounds, which feature three nitrogen atoms attached to one quaternary carbon forming a spirocyclic scaffold, exhibit a wide range of biological activity and have promising applications in materials as well as in drug discovery. In this review article, we will discuss triazaspirocycles in Nature, their biological activity, and applications. Methods for the synthesis of triazaspirocycles as well as the reactivity of triazaspirocyclic scaffolds will be reviewed.
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