Quantitative Comparison of Swept-Source and Spectral-Domain OCT Angiography in Healthy Eyes

To compare macular vessel density (VD) and foveal avascular zone (FAZ) area in healthy individuals using two different optical coherence tomography angiography (OCTA) devices.

In this prospective, comparative study, 25 eyes of 14 healthy subjects underwent fovea-centered 3 mm × 3 mm OCTA-imaging using the Triton (Topcon, Tokyo, Japan) and RS-3000 (Nidek, Gamagori, Japan) OCTA devices. Superficial and deep retinal layers (SRL/DRL) and FAZ were manually graded after threshold standardization to determine macular VD and area of the FAZ.

The mean difference in the VD between the two devices was 0.105 and 0.096, and the coefficient of variation (CV) was 19.59% and 16.90% for the SRL and DRL, respectively. After skeletonization of vessels to remove variation related to vessel width, the mean difference was 0.174 mm^-1 and 0.516 mm^-1, and the CV was 3.49% and 1.07% for SRL and DRL, respectively. The mean difference of FAZ area was 0.001 mm² and 0.010 mm² in the SRL and DRL, respectively, and the CV was 2.17% and 5.74% for the SRL and DRL, respectively.

Macular VD using skeletonized mapping and FAZ area in SRL and DRL were statistically similar between the two devices, demonstrating a possible comparison of quantitative values between different OCTA devices. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:385-391.].