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Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations
Ahil N Ganesh1,2, Jennifer Logie1,2, Christopher K McLaughlin1,2
1Department of Chemical Engineering and Applied Chemistry, University of Toronto , 200 College Street, Toronto, Ontario, Canada M5S 3E5.
Molecular Pharmaceutics
|May 16, 2017
Summary
Researchers developed polymer-stabilized colloidal drug aggregates to overcome low drug loading in nanoparticle formulations. This novel approach enhances drug delivery by creating stable, high-loading nanoparticles for potential therapeutic applications.
Area of Science:
- Nanotechnology
- Materials Science
- Drug Delivery
Background:
- Limited drug loading in nanoparticle formulations remains a significant challenge for chemotherapy.
- Colloidal drug aggregates often exhibit poor stability in physiological media.
Purpose of the Study:
- To investigate the use of polymer-stabilized colloidal drug aggregates for high drug loading in nanoparticles.
- To assess the stability and applicability of this formulation strategy.
Main Methods:
- Utilized colloidal drug aggregation combined with polymeric excipients (polysorbate 80 and PLAC-PEG).
- Formulated nanoparticles using fulvestrant and a novel prodrug, pentyl-PABC doxazolidine (PPD).
- Evaluated nanoparticle size, stability in buffered saline and serum-containing media at 37 °C.
Main Results:
- Achieved high drug loading in nanoparticles with diameters < 200 nm.
- Demonstrated nanoparticle stability for up to 2 days in buffered saline and 24 hours in serum-containing media.
- Attributed colloid stability to polymeric excipients and reduced protein adsorption.
Conclusions:
- Polymer-stabilized colloidal drug aggregates offer a viable strategy for high drug loading in nanoparticle formulations.
- This approach enhances nanoparticle stability in physiological conditions.
- The method is expected to have broad applicability in drug delivery systems.
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