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Splenic volume differentiates complicated and non-complicated celiac disease.
Tom van Gils1, Petula Nijeboer1, Jan Hein Tm van Waesberghe2
1Celiac Center Amsterdam, Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands.
United European Gastroenterology Journal
|May 17, 2017
Summary
Splenic volume (SV) is enlarged in uncomplicated celiac disease (CD) but reduced in refractory CD type II (RCD II). This finding may have clinical implications for RCD II patients.
Area of Science:
- Gastroenterology
- Immunology
- Radiology
Background:
- Previous studies suggested reduced splenic volume (SV) in celiac disease (CD), refractory CD type II (RCD II), and enteropathy-associated T-cell lymphoma (EATL).
- However, these observations were based on small patient cohorts.
Purpose of the Study:
- To investigate splenic volume (SV) in a large cohort of patients with uncomplicated CD, RCD II, and EATL.
- To compare SV in these patient groups with healthy controls.
Main Methods:
- A retrospective cohort study included 77 uncomplicated CD patients, 29 RCD II patients, 24 EATL patients, and 12 with both RCD II and EATL.
- A control group comprised 149 healthy living kidney donors.
- Splenic volume (SV) was quantified using computed tomography.
Main Results:
- Uncomplicated CD patients exhibited a significantly larger median SV compared to controls (202 cm³ vs. 183 cm³).
- After adjustments for covariates, SV was 1.28 times larger in uncomplicated CD patients than in controls (p < 0.001).
- RCD II patients showed a significantly smaller median SV than controls (118 cm³ vs. 183 cm³, p < 0.001).
Conclusions:
- Splenic volume (SV) demonstrates significant inter-individual variability.
- SV is enlarged in uncomplicated celiac disease (CD).
- The reduced SV observed in refractory CD type II (RCD II) warrants clinical consideration due to the immunocompromised state of these patients.
