Analysis of immune-biochemical indicators to assess the risk of developing cardiological pathology

Area of Science:

• Cardiology
• Immunology
• Biochemistry

Background:

• Assessing the severity of cardiac diseases is crucial for effective patient management.
• Existing diagnostic and prognostic methods rely on clinical and laboratory blood parameters.
• The role of natural antibodies (n-Abs) in predicting cardiac disease severity requires further investigation.

Purpose of the Study:

• To develop novel immuno-biochemical tests for assessing cardiac disease severity.
• To compare the efficacy of traditional biochemical markers with n-Abs levels.
• To establish the combined predictive value of immunological and biochemical markers.

Main Methods:

• Comparative analysis of clinical and laboratory blood parameters.
• Quantification of natural antibodies (n-Abs) against β-endorphin, bradykinin, histamine, dopamine, and serotonin.
• Correlation analysis between n-Abs levels, biochemical parameters, and blood cell counts.

Main Results:

• A significant correlation was found between the levels of n-Abs and key biochemical parameters.
• The study revealed significant correlations between n-Abs levels and blood corpuscle content.
• Combined use of immunological and biochemical tests demonstrated increased prediction reliability.

Conclusions:

• Prognostic immuno-biochemical tests offer a more reliable method for assessing cardiac disease severity.
• The integration of n-Abs analysis with standard biochemical tests enhances predictive accuracy.
• These findings support the clinical utility of combined immunological and biochemical testing in cardiology.