SU-E-I-112: Pre-Clinical Imaging with an Ultra-High Resolution X-Ray Detector
V Singh1, B Loughran1, L Pope1
1Toshiba Stroke Research Center, University at Buffalo, Buffalo, NY.
Medical Physics
|May 19, 2017
Summary
This study introduces a new ultra-high resolution micro-solid state x-ray image intensifier (micro-SSXII) detector. The micro-SSXII successfully imaged rat kidney vasculature with 25-micron detail, showing potential for small animal interventional studies.
Area of Science:
- Medical Imaging
- Radiology
- Biomedical Engineering
Background:
- Developing advanced imaging technologies is crucial for detailed visualization in preclinical research.
- Ultra-high resolution detectors are needed for studying fine anatomical structures.
Purpose of the Study:
- To explore applications of a novel ultra-high resolution, small field-of-view (FOV) micro-solid state x-ray image intensifier (micro-SSXII) detector.
- To evaluate the imaging capabilities of the micro-SSXII for small animal vasculature.
Main Methods:
- The micro-SSXII utilizes an 8-micron electron-multiplying CCD (EMCCD) coupled to a CsI(Tl) phosphor.
- Real-time imaging at low exposures is enabled by the EMCCD's high gain.
- Phantoms with contrast agents (Omnipaque, barium sulfate, tantalum) in resin were imaged, followed by a rat kidney vasculature cast.
Main Results:
- Images revealed contrast agent clumping, with an Omnipaque and resin mixture (1:4 ratio) showing the best uniformity.
- The micro-SSXII clearly delineated small iodine bubbles (as small as 25 microns) in the rat kidney vasculature.
- The detector confirmed its capability for sharp detail imaging.
Conclusions:
- The micro-SSXII, with a soft x-ray spectrum, provides excellent images of small animal casts for studying vasculature details.
- This detector shows potential for region-of-interest x-ray image guidance in small animal interventional studies.
Related Concept Videos
01:24X-ray Imaging
10.8K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
10.8K
01:29Determination of Crystal Structures
12
In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
12