MO-D-217BCD-01: Personalizing Medicine: Adapting to the Individual.

Area of Science:

• Oncology
• Medical Physics
• Radiotherapy

Background:

• Personalized medicine, driven by patient-specific adaptation, is shifting from research to clinical practice.
• Advancements in clinical tools like auto-segmentation and deformable registration enhance the efficiency of adaptive techniques.
• Safe implementation requires understanding the rationale and consequences of anatomical and physiological adaptation, including radiobiological effects.

Purpose of the Study:

• To review the evidence and rationale for anatomy-based adaptation in radiotherapy.
• To explore methods for implementing physiological-based adaptation using functional imaging for personalized treatment.
• To discuss the radiobiological considerations and clinical implications of dose summation and adaptive strategies.

Main Methods:

• Review of retrospective studies on anatomy-based adaptation across various anatomical sites.
• Discussion of functional imaging techniques for personalized treatment adaptation.
• Analysis of radiobiological factors influencing adaptive strategies and dose accumulation.

Main Results:

• Evidence supports the benefits of anatomy-based adaptation in addressing dose uncertainties.
• Functional imaging enables sophisticated personalization based on individual tumor and normal tissue response.
• Radiobiological impacts and clinical perspectives on adaptation are critical for patient outcomes.

Conclusions:

• Anatomy- and physiology-based adaptation are essential for advancing personalized medicine in radiotherapy.
• Safe clinical implementation necessitates a thorough understanding of radiobiological effects and adaptive strategies.
• Adaptive radiotherapy holds significant potential for improving patient treatments, clinical trials, and outcomes assessment.