WE-G-217BCD-08: Image Quality Effects of Dynamic Iodine Concentrations for Contrast-Enhanced Cone-Beam CT
B Jones1, C Altunbas1, B Kavanagh1
1University of Colorado School of Medicine, Aurora, CO.
Medical Physics
|May 19, 2017
Summary
Optimizing contrast-enhanced cone-beam CT (CE-CBCT) imaging parameters is crucial for accurately localizing liver lesions in stereotactic body radiation therapy (SBRT). This study developed a model to improve CE-CBCT image quality and signal-to-noise ratio for better SBRT targeting.
Area of Science:
- Medical Imaging
- Radiation Oncology
- Radiophysics
Background:
- Cone-beam CT (CBCT) is used for image-guided radiation therapy.
- Intravenous (IV) contrast agents enhance lesion visibility.
- Dynamic contrast enhancement in CBCT (CE-CBCT) is challenging due to image artifacts and low temporal resolution.
Purpose of the Study:
- To investigate the dynamic imaging effects of IV contrast agents for CE-CBCT.
- To enable accurate localization of liver lesions for stereotactic body radiation therapy (SBRT).
- To optimize CE-CBCT parameters for improved liver lesion detection.
Main Methods:
- A model was developed to study dynamic IV contrast agents using static phantoms.
- Iodine samples (0-5 mg/mL) were imaged to simulate contrast concentrations.
- CBCT projections were reassembled to reconstruct dynamic contrast concentrations.
- The model was applied to hepatic contrast enhancement curves to derive optimal parameters.
Main Results:
- Un-optimized CE-CBCT scans showed a 25%-75% decrease in signal-to-noise ratio (SNR).
- Artifacts like scatter and detector glare were minimized.
- Optimized parameters for injection, scanning, and timing resulted in a 100% SNR increase.
Conclusions:
- IV contrast effects are significantly degraded in CBCT, necessitating parameter optimization.
- Careful consideration of contrast pharmacokinetics and CBCT's low temporal resolution is vital.
- The developed model demonstrates the feasibility of CE-CBCT for routine liver lesion localization in SBRT.
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