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Post-herpetic neuralgia: 208 cases.

Peter N C Watson1, Ramon J Evans, Verna R Watt

  • 1Smythe Pain Clinic, Toronto General Hospital, University of Toronto, Toronto, Ont. M5G 2C4 Canada.

Pain
|December 1, 1988
PubMed
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Post-herpetic neuralgia (PHN) affects all ages, with pain and sensory loss common. Antidepressants and topical capsaicin show promise for PHN management.

Area of Science:

  • Neurology
  • Pain Medicine
  • Dermatology

Background:

  • Post-herpetic neuralgia (PHN) is a chronic neuropathic pain condition.
  • It commonly affects older individuals and can significantly impact quality of life.

Purpose of the Study:

  • To evaluate the demography, clinical features, and treatment outcomes of post-herpetic neuralgia.
  • To assess the long-term status and identify effective management strategies for PHN.

Main Methods:

  • Prospective, longitudinal study of 208 patients diagnosed with PHN.
  • Data collection included patient demographics, clinical presentation, pain characteristics, and treatment responses.

Main Results:

  • PHN prevalence and severity increase with age, affecting both sexes equally.

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  • Commonly involved areas include the ophthalmic division of the trigeminal nerve and mid-thoracic dermatomes.
  • Antidepressants (amitriptyline, nortriptyline) were effective in approximately 60% of patients; topical capsaicin showed promise.
  • Scarring, sensory loss, hyperesthesia, dysesthesia, and allodynia were frequent findings.

    • Conclusions:

    • Antidepressants and topical capsaicin represent viable treatment options for PHN.
    • Many PHN patients experience long-term improvement, even with longstanding conditions.
    • Further research into PHN management is warranted to improve patient outcomes.