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Negative Symptoms in Patients With Alzheimer's Disease
Igor I Galynker1, David M Roane1, Christian R Miner1
1Department of Psychiatry, Beth Israel Medical Center, New York, NY.
Summary
Negative symptoms, common in schizophrenia, are prevalent in Alzheimer's type dementia (DAT). These symptoms correlate with cognitive deficits but not depression in DAT patients.
Area of Science:
- Neurology
- Psychiatry
Background:
- Negative symptoms are a recognized feature in schizophrenia.
- Their presence and impact in dementia of the Alzheimer type (DAT) remain less understood.
Purpose of the Study:
- To investigate the prevalence of negative symptoms in DAT.
- To explore the relationship between negative symptoms, cognitive deficits, and depression in DAT patients.
Main Methods:
- The study utilized the Positive and Negative Symptom Scale (PANSS-N) for negative symptoms.
- Cognitive function was assessed using the Mini-Mental State Examination (MMSE).
- Depression was evaluated with the Hamilton Depression Scale (Ham-D) in 26 DAT patients and 13 controls.
Main Results:
- DAT patients exhibited significantly higher PANSS-N scores compared to controls.
- A significant correlation was found between negative symptoms and cognitive deficits in DAT patients.
- Hamilton Depression Scale scores did not significantly correlate with MMSE or PANSS-N scores.
Conclusions:
- Negative symptoms are a prevalent feature in dementia of the Alzheimer type.
- These symptoms are associated with cognitive impairment in DAT.
- The findings suggest that negative symptoms in DAT are distinct from depressive symptoms.
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