Mobius Syndrome: A 35-Year Single Institution Experience.

Area of Science:

• Orthopedics
• Genetics
• Pediatric Medicine

Background:

• Mobius syndrome is a rare congenital disorder.
• It is associated with various orthopedic conditions, including scoliosis, clubfoot, and limb deficiencies.
• No extensive studies have detailed the orthopedic manifestations of Mobius syndrome.

Purpose of the Study:

• To characterize the spectrum of orthopedic conditions associated with Mobius syndrome.
• To analyze the management and outcomes of these orthopedic conditions.

Main Methods:

• Retrospective review of medical records for 44 patients diagnosed with Mobius syndrome (1980-2015).
• Analysis of patient demographics, associated orthopedic conditions, and treatment strategies.
• Radiographic review for specific orthopedic findings.

Main Results:

• Increased incidence of clubfoot (41%), Poland syndrome (20%), and scoliosis (14%) in Mobius syndrome patients.
• Clubfoot management often required surgical intervention (posteromedial release) and revisions, even with Ponseti casting.
• Other conditions included hip dysplasia, arthrogryposis, Pierre Robin syndrome, and chromosome 10 defects.

Conclusions:

• Mobius syndrome is linked to a higher prevalence of orthopedic problems, particularly clubfoot, scoliosis, and upper extremity differences.
• Clubfoot treatment in Mobius syndrome patients may necessitate surgery and revisions due to casting failure.
• Early orthopedic involvement and counseling families on complex treatment are essential.