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Nanoparticles as new tools for inhibition of cancer angiogenesis

Nasser Hashemi Goradel1, Farshid Ghiyami-Hour2, Samira Jahangiri3

  • 1Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Cellular Physiology
|May 26, 2017
PubMed

Insights

This review explores targeting cancer angiogenesis, a key hallmark of cancer. Nanotechnology, particularly nanoparticles (NPs), offers promising strategies to inhibit tumor growth by blocking blood supply, with novel approaches like hydrogel-conjugated NPs showing potential.

Area of Science:

  • Oncology
  • Biotechnology
  • Nanomedicine

Background:

  • Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and survival.
  • Vascular Endothelium Growth Factor (VEGF) and its Tyrosine Kinase Receptors (TKRs) are central to cancer angiogenesis.
  • Targeting angiogenesis presents a significant therapeutic strategy in cancer treatment.

Purpose of the Study:

  • To review the mechanisms of angiogenesis in cancer.
  • To discuss current anti-angiogenesis therapeutic strategies.
  • To highlight the application of nanoparticles in targeting cancer angiogenesis.

Main Methods:

  • Literature review of angiogenesis mechanisms.
  • Analysis of established anti-angiogenesis therapies.
  • Evaluation of nanoparticle-based strategies for cancer treatment.
  • Exploration of novel approaches like hydrogel-conjugated nanoparticles.

Main Results:

  • Nanoparticles (NPs) demonstrate efficacy in inhibiting angiogenesis by depriving tumors of nutrients and oxygen.
  • NPs can be utilized as effective delivery tools for anti-cancer agents.
  • Limitations associated with NP utilization are identified, suggesting areas for improvement.

Conclusions:

  • Targeting angiogenesis is a vital strategy in cancer therapy.
  • Nanotechnology, especially NPs, offers a promising avenue for anti-angiogenesis cancer treatment.
  • Conjugating NPs with hydrogels may overcome existing limitations, enhancing therapeutic potential.
Keywords:
TKRsVEGFangiogenesisnanoparticles

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