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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genomic DNA in Eukaryotes00:58

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Genetic Variation01:25

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Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
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DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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HEROD: a human ethnic and regional specific omics database.

Xian Zeng1,2, Lin Tao1,3, Peng Zhang2

  • 1The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, P. R. China.

Bioinformatics (Oxford, England)
|May 27, 2017
PubMed
Summary

A new database, HEROD, provides access to human ethnic and regional specific OMICS data. This resource facilitates precision medicine by enabling research on genetic variations across diverse populations.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Precision Medicine

Background:

  • Genetic variations influence phenotypes, diseases, and drug responses.
  • OMICS studies are crucial for developing precision medicine.
  • Limited access to ethnic and regional specific OMICS data hinders research.

Purpose of the Study:

  • To introduce HEROD, a novel human ethnic and regional specific OMICS database.
  • To provide a centralized and accessible platform for diverse genomic data.

Main Methods:

  • Curated gene expression data from major public repositories (GEO, ArrayExpress, TCGA, ICGC).
  • Extensive data includes 53,070 patients across 169 diseases, 7 ethnic groups, 193 cities/regions, and 49 nations.
  • Geographic and ethnic information was manually extracted from original publications.

Main Results:

  • HEROD offers comprehensive ethnic and regional OMICS data.
  • Data is searchable via keywords, world map, and menus by disease, ICD code, geography, ethnicity, demographics, and sample type.
  • The database supports various search parameters for detailed analysis.

Conclusions:

  • HEROD addresses the need for accessible, ethnicity-specific OMICS data.
  • Facilitates research into population-specific genetic variations and disease associations.
  • Supports the advancement of precision medicine through broader data accessibility.