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Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy

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Tracking motion trajectories of individual nanoparticles using time-resolved current traces.

Wei Ma¹, Hui Ma¹, Jian-Fu Chen²

¹Key Laboratory for Advanced Materials , Institute of Fine Chemicals , East China University of Science and Technology , Shanghai , P. R. China . Email: tianhe@ecust.edu.cn ;

Chemical Science

|May 30, 2017

Summary

Investigating single nanoparticle (NP) electrochemical signals is challenging. This study reveals that distinct NP motion trajectories can be identified from electrochemical current traces, highlighting the importance of NP movement in electrochemistry.

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Area of Science:

Electrochemistry
Nanotechnology
Computational Science

Background:

Single nanoparticle (NP) electrochemical measurements offer detailed insights masked in ensemble studies.
Investigating individual NP electrochemical behavior presents significant challenges due to complex signal interpretation.

Purpose of the Study:

To demonstrate that distinct motion trajectories of individual silver nanoparticles (AgNPs) can be discerned from electrochemical data.
To highlight the influence of NP motion on electrochemical signals.

Main Methods:

Utilizing dynamic Monte Carlo simulations to analyze time-resolved current traces.
Employing a low-noise electrochemical measurement platform for continuous monitoring of individual AgNP oxidation.
Quantifying electrochemical signals to correlate with NP motion.

Main Results:

Multiple distinct motion trajectories were identified from simulated time-resolved current traces.
Continuous monitoring revealed distinguished current traces for individual AgNPs.
Size-dependent motions of AgNPs were shown to significantly influence their electrochemical signals.

Conclusions:

Electrochemical signals of individual NPs are significantly influenced by their motion behaviors.
The findings provide a new perspective on single NP electrochemistry, differing from existing literature.
Understanding NP motion is crucial for accurate interpretation of single NP electrochemical measurements.