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Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
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Neuropeptides: A promising target for treating seizures
Neethi Menon1, Kedar S Prabhavalkar1, Lokesh K Bhatt1
1SVKM's Dr Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai-56, India.
Neuropeptides
|June 1, 2017
Summary
Neuropeptides can help manage seizures by correcting neurotransmitter imbalances. This review explores neuropeptides as potential therapeutic targets for seizure disorders and epileptogenesis.
Area of Science:
- Neuroscience
- Neurology
- Pharmacology
Background:
- Seizures affect 50 million people globally, stemming from neuronal firing imbalances.
- Excitatory and inhibitory neurotransmitter dysregulation underlies seizure activity.
- Neuropeptides are implicated in regulating neurotransmitter balance.
Purpose of the Study:
- To review neuropeptides that can alleviate seizure effects.
- To explore neuropeptides' role in managing epileptogenesis.
- To identify neuropeptides as potential therapeutic targets for seizure management.
Main Methods:
- Literature review of neuropeptide function in neurological disorders.
- Analysis of neuropeptide storage and release mechanisms.
- Focus on neuropeptides modulating excitatory/inhibitory neurotransmission.
Main Results:
- Certain neuropeptides demonstrate potential in rectifying neurotransmitter imbalances.
- Neuropeptides can mitigate seizure-related neuronal hyperexcitability.
- Evidence suggests neuropeptides can impact epileptogenesis.
Conclusions:
- Neuropeptides offer a promising avenue for seizure management.
- Targeting neuropeptides may provide novel therapeutic strategies for epilepsy.
- Further research into neuropeptide-based treatments is warranted.
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