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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
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Chronic Autoimmune Meningoencephalitis and Periodic Fever Syndrome Treated with Anakinra
Alyssa-Rae Novroski1, Kelly J Baldwin1
1Department of Neurology, Geisinger Medical Center, Danville, Pennsylvania, USA.
Case Reports in Neurology
|June 1, 2017
Summary
Anakinra, an interleukin-1 receptor antagonist, successfully treated a patient with chronic autoimmune meningoencephalitis and cyclical fever syndrome unresponsive to conventional therapies. This case highlights anakinra as a potential treatment for refractory autoimmune meningitis.
Area of Science:
- Neurology
- Immunology
- Rheumatology
Background:
- Chronic autoimmune meningoencephalitis and periodic cyclical fever syndrome are rare, often treatment-refractory conditions.
- Conventional treatments frequently fail, leading to prolonged hospitalizations and disease progression.
Observation:
- A 63-year-old male presented with refractory chronic autoimmune meningoencephalitis and periodic cyclical fever syndrome.
- The patient experienced 2 years of failed conventional treatments and recurrent hospitalizations.
Findings:
- Treatment with anakinra, an interleukin-1 (IL-1) receptor antagonist, resulted in complete recovery.
- IL-1 blockade demonstrated significant efficacy in this challenging case.
Implications:
- Anakinra represents a promising therapeutic option for chronic autoimmune meningitis, particularly when refractory to standard care.
- This case expands the potential applications of IL-1 antagonists in autoimmune neurological disorders.
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