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Related Experiment Video

Updated: Mar 1, 2026

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

23.0K

Microfluidic-based high-throughput optical trapping of nanoparticles.

Abhay Kotnala1, Yi Zheng, Jianping Fu

  • 1Department of Pharmaceutical Sciences, University of Michigan, 428 church street, Ann Arbor, MI 48109, USA.

Lab on a Chip
|June 1, 2017
PubMed
Summary

This study introduces a microfluidic system to enhance optical tweezers, significantly increasing nanoparticle analysis throughput. The new method achieves over tenfold higher efficiency for trapping and analyzing nanoparticles.

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Analytical Chemistry

Background:

  • Optical tweezers offer single-molecule sensitivity for nanoparticle analysis.
  • Low throughput limits the application of optical tweezers, especially for dilute samples.

Purpose of the Study:

  • To develop a microfluidic-based optical tweezers system for active nanoparticle delivery.
  • To enhance the throughput and efficiency of nanoparticle trapping and analysis.
  • To enable precise nanoparticle size quantitation without prior refractive index knowledge.

Main Methods:

  • Integration of microfluidics for active nanoparticle delivery to the trapping region.
  • Utilizing back-focal plane interferometry with a trapping laser.
  • Demonstrating multiparametric analysis of individual nanoparticles.

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A Microfluidic-based Hydrodynamic Trap for Single Particles

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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

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Related Experiment Videos

Last Updated: Mar 1, 2026

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

23.0K
A Microfluidic-based Hydrodynamic Trap for Single Particles
10:13

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

17.3K
Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

8.0K

Main Results:

  • Achieved a tenfold increase in optical trapping throughput compared to conventional systems.
  • Demonstrated precise nanoparticle size quantitation independent of refractive index.
  • Showcased the system's efficiency with low concentration nanoparticle samples.

Conclusions:

  • The microfluidic-based active optical tweezers system significantly boosts nanoparticle analysis throughput.
  • This technology facilitates high-throughput multiparametric analysis of nanoparticles.
  • Enables advanced nanoparticle characterization for diverse applications.