Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

90.2K
Overview
90.2K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
What is Population Genetics?01:25

What is Population Genetics?

65.1K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.1K
Incomplete Dominance01:43

Incomplete Dominance

30.8K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
30.8K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.2K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.2K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.0K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical testing of drug treatment shortening in patients with TB using PET/CT imaging of lung lesions.

Science translational medicine·2026
Same author

Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques.

Communications medicine·2025
Same author

Strange relatives: the enigmatic arbo-jingmenviruses and orthoflaviviruses.

Npj viruses·2025
Same author

PET/CT guided tuberculosis treatment shortening: a randomized trial.

medRxiv : the preprint server for health sciences·2025
Same author

Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein.

Science (New York, N.Y.)·2025
Same author

B cell immunofocusing and repriming in two HIV-1 Env immunization regimens.

Research square·2024

Related Experiment Video

Updated: Mar 1, 2026

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.8K

SAMPLING PROPERTIES OF GENEALOGICAL PATHWAYS UNDERLYING POPULATION PEDIGREES.

Kurt Wollenberg1, John C Avise1

  • 1Department of Genetics, University of Georgia, Athens, Georgia, 30602.

Evolution; International Journal of Organic Evolution
|June 1, 2017
PubMed
Summary

Understanding genetic transmission requires analyzing autosomal alleles passed through pedigrees. Models show that sampling more gender-defined lineage routes improves the accuracy of reconstructing true organismal pedigrees and coancestry coefficients.

Keywords:
Coancestry coefficientevolutiongenealogymolecular phylogenypedigree

More Related Videos

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.9K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K

Related Experiment Videos

Last Updated: Mar 1, 2026

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.8K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.9K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K

Area of Science:

  • Population genetics
  • Computational biology
  • Quantitative genetics

Background:

  • Autosomal alleles are transmitted across generations in sexually reproducing species through complex pedigrees involving both male and female lineages.
  • Accurately reconstructing these pedigrees is crucial for understanding genetic variation and evolutionary processes.
  • Existing models often simplify the sampling of transmission pathways, potentially leading to inaccuracies.

Purpose of the Study:

  • To assess the sampling properties of gender-described autosomal allele transmission pathways in population pedigrees.
  • To evaluate how the number of sampled lineage routes affects the accuracy of estimating true coancestry coefficients and common ancestry times.
  • To investigate the relationship between population structure and the reliability of reconstructed pedigrees.

Main Methods:

  • Development of computer-simulated population pedigrees using an isolation-by-distance model.
  • Systematic variation of neighborhood size and timing of isolation events in simulated populations.
  • Calculation of true coancestry coefficients for all individuals in the final generation of each pedigree.
  • Estimation of pairwise times to common ancestry by sampling varying numbers of gender-defined lineage routes.
  • Comparison of estimated versus true pedigree relationships using cophenetic correlations.

Main Results:

  • Poor agreement and high variance between estimated and true pedigrees were observed when few lineage routes were sampled.
  • Agreement significantly improved as the number of sampled lineage routes increased.
  • The accuracy asymptotically approached plateau levels that were predictable based on the degree of population structure.
  • A clear distinction emerged between the comprehensive genealogical information in a full pedigree and the information captured by limited allelic lineage pathways.

Conclusions:

  • The number of sampled gender-defined lineage routes critically impacts the accuracy of reconstructing population pedigrees and estimating genetic relatedness.
  • Increasing the sampling of transmission pathways enhances the reliability of genealogical reconstructions.
  • Population structure influences the precision with which genetic relationships can be inferred from sampled lineages.