Related Experiment Video
Updated: Mar 1, 2026
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Retinal Nerve Fiber Layer Thickness Measurement by Spectral-Domain Optical Coherence Tomography in Patients with
İpek Sönmez1, Ferdi Köşger2, Ümit Aykan3
1Department of Psychiatry, Near East University School of Medicine, Nicosia, Turkish Republic of Northern Cyprus.
Introduction:
In recent years, an increasing number of studies have researched retinal nerve fiber layer (RNFL) changes in neurodegenerative disorders. In this study, our aim was to determine structural RNFL changes in patients with major depressive disorder.
Methods:
A total of 30 patients with major depressive disorder and 30 age- and sex-matched controls were recruited. Using optical coherence tomography (OCT), the peripapillary RNFL thickness in major depressive disorder patients and control subjects was measured and compared at each location.
Results:
Patients with major depressive disorder did not show a statistically significant reduction in overall peripapillary RNFL thickness.
Conclusion:
Our study showed that RNFL thickness is not reduced in major depressive disorder patients and that OCT is not a useful tool for diagnosing and monitoring the progression of major depressive disorder. This study suggests that the pathophysiology of unipolar depression is different than in neurodegenerative disorders, pervasive developmental disorders, schizophrenia, and bipolar disorder.
More Related Videos
07:44In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
07:08Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
Published on: January 10, 2019
