Decarbonylative Cyanation of Amides by Palladium Catalysis
Shicheng Shi1, Michal Szostak1
1Department of Chemistry, Rutgers University , 73 Warren Street, Newark, New Jersey 07102, United States.
Abstract:
Transition-metal-catalyzed cyanation of aryl halides is a process of significant importance in the preparation pharmaceuticals, organic materials and agrochemicals. Here, we demonstrate a palladium-catalyzed decarbonylative cyanation of amides by highly selective carbon-nitrogen bond cleavage for the synthesis of a wide range of aryl nitriles. The utility of this technology is demonstrated by the synthesis of isotopically labeled aryl nitriles and orthogonal cross-coupling reactions of bench-stable amides to establish cross-coupling synthons with opposite polarity.
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