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Pneumonia is an independent risk factor for pyogenic liver abscess: A population-based, nested, case-control study
Sai-Wai Ho1,2,3, Chao-Bin Yeh1,2, Shun-Fa Yang3,4
1Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Pneumonia increases the risk of developing pyogenic liver abscess (PLA). Hospitalization for pneumonia, especially within 180 days prior, significantly elevates PLA risk, highlighting a crucial association.
Area of Science:
- Infectious Diseases
- Hepatology
- Pulmonology
Background:
- Bacteremic pneumonia can lead to abscesses in other organs.
- Pneumonia is investigated as a potential risk factor for pyogenic liver abscess (PLA).
Purpose of the Study:
- To explore the association between pneumonia and the development of pyogenic liver abscess (PLA).
Main Methods:
- A nationwide, population-based, nested case-control study.
- Utilized Taiwan National Health Insurance Research Database.
- Included 494 PLA patients and 1,976 propensity score-matched controls.
- Conditional logistic regression analysis was performed.
Main Results:
- Hospitalization for pneumonia was an independent risk factor for PLA (aOR = 2.104).
- The risk was significantly higher with recent pneumonia hospitalization: within 30 days (aOR = 10.73), 30-90 days (aOR = 4.698), and 90-180 days (aOR = 4.000).
Conclusions:
- Pneumonia is confirmed as an independent risk factor for subsequent pyogenic liver abscess (PLA).
- Recent hospitalization for pneumonia (within 180 days) is strongly associated with an increased risk of PLA.
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