Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep deprivation does not affect seizure frequency during inpatient video-EEG monitoring.

Neurology·2002
Same author

Trends in cardiac morbidity and mortality after endoluminal abdominal aortic aneurysm repair; discussion 999-1000.

Archives of surgery (Chicago, Ill. : 1960)·2001
Same author

Nesidioblastosis coexisting with islet cell tumor and intraductal papillary mucinous hyperplasia.

Archives of pathology & laboratory medicine·2001
Same author

Correlation between admission laboratory values, early abdominal computed tomography, and severe complications of gallstone pancreatitis.

American journal of surgery·2001
Same author

Surgical management of gastrointestinal bleeding.

Gastroenterology clinics of North America·2001
Same author

Simplified admission criterion for predicting severe complications of gallstone pancreatitis.

Archives of surgery (Chicago, Ill. : 1960)·2000
Same journal

High and low body mass index and 90-day postoperative outcomes in patients with Crohn's disease undergoing abdominal surgery.

American journal of surgery·2026
Same journal

Women with firearm injuries: A multicenter mixed-methods study.

American journal of surgery·2026
Same journal

SBAS presidential address: A surgeon-scientist's journey from haptic science to digital performance metrics.

American journal of surgery·2026
Same journal

Using Dr. Google and AI to stay informed.

American journal of surgery·2026
Same journal

Revealing the sex divide: Primary hyperparathyroidism across the American population.

American journal of surgery·2026
Same journal

Pressure points: A pilot study using the NASA-TLX tool to measure the intensity of Acute care surgery work.

American journal of surgery·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Benign and malignant gastrinoma.

B E Stabile, E Passaro

    American Journal of Surgery
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Hepatic metastases in gastrinoma patients indicate malignant disease and poor prognosis. Patients with gastrinoma limited to lymph nodes have a better outlook and a higher chance of surgical cure.

    More Related Videos

    Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
    08:57

    Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

    Published on: May 17, 2024

    Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
    03:05

    Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

    Published on: February 16, 2024

    Related Experiment Videos

    Last Updated: Jun 25, 2026

    Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
    10:28

    Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

    Published on: January 22, 2018

    Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
    08:57

    Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

    Published on: May 17, 2024

    Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
    03:05

    Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

    Published on: February 16, 2024

    Area of Science:

    • Gastroenterology
    • Surgical Oncology
    • Endocrinology

    Background:

    • Accurate gastrinoma diagnosis is crucial for treatment planning, especially with advances in H2-receptor antagonists and surgery.
    • Differentiating benign from malignant gastrinoma impacts patient management and prognosis.

    Purpose of the Study:

    • To analyze the prognostic significance of tumor location in gastrinoma patients.
    • To identify predictors of survival and surgical cure in gastrinoma.

    Main Methods:

    • Retrospective analysis of 65 gastrinoma patients with an average follow-up of 93 months.
    • Classification of patients based on tumor presence: hepatic tumors, lymph node involvement, or primary tumors only.
    • Life-table analysis to compare survival rates between groups.

    Main Results:

    • Patients with hepatic metastases (n=14) had a significantly worse prognosis (79% tumor-related mortality) compared to those with lymph node involvement (n=15, 7% mortality).
    • No liver metastases developed in most patients with initial lymph node involvement.
    • Surgical cure was achieved in 23% of patients without multiple endocrine adenopathy syndrome or liver metastases.

    Conclusions:

    • Hepatic metastases are a definitive marker of malignant gastrinoma with a poor prognosis.
    • Gastrinoma confined to lymph nodes typically follows a less malignant course, with a potential for surgical cure.
    • Early identification of metastatic disease is critical for patient management and survival prediction.