Next Generation "Omics" Approaches in the "Fight" against Blood Doping
Medicine and Sport Science
|June 2, 2017
Summary
Athletes use blood manipulation for performance enhancement, but detection is challenging. Advanced "omics" methods like transcriptomics show promise in identifying new molecular signatures to improve anti-doping detection beyond the athlete biological passport.
Area of Science:
- Sports Science
- Biochemistry
- Molecular Biology
Background:
- Blood manipulation, including recombinant human erythropoietin and transfusions, is a prohibited performance-enhancing method in sports.
- Direct detection of blood doping is limited by short detection windows, sample timing, and masking strategies.
- The Athlete Biological Passport (ABP) was introduced to detect doping via longitudinal monitoring of hematologic biomarkers.
Purpose of the Study:
- To address the limitations of the ABP in detecting sophisticated blood doping methods, such as microdosing.
- To explore the potential of transcriptomics and other 'omics' technologies to identify novel molecular signatures of blood manipulation.
- To enhance current anti-doping strategies for detecting blood doping in athletes.
Main Methods:
- Utilizing transcriptomic microarrays to analyze gene expression changes following blood manipulation.
- Investigating other 'omics' approaches, including proteomics and metabolomics, for identifying molecular markers.
- Comparing the efficacy of 'omics' signatures with the existing Athlete Biological Passport (ABP) method.
Main Results:
- Transcriptomic microarrays can reveal distinct gene expression changes indicative of blood manipulation.
- These molecular signatures show potential for enhancing the sensitivity and scope of the ABP.
- Emerging 'omics' technologies offer new avenues for detecting elusive doping practices.
Conclusions:
- There is an urgent need for intensified research into 'omics' technologies for anti-doping.
- Transcriptomics, proteomics, and metabolomics can provide robust molecular signatures of blood manipulation.
- These 'omics' signatures could supplement or even serve as stand-alone tests to improve blood doping detection.
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