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Updated: Mar 1, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[IMMUNE RESPONSE IN CHRONIC BRONCHIOLITIS OBLITERANS IN CHILDREN]
I Mustafayev1, L Allahverdyeva1, A Bogdanova1
11Research Institute of Lung Diseases, Baku; 2State Medical University, Baku, Azerbaijan; 3Research Institute of Pulmonology of The Pavlov First Saint Petersburg State Medical University, Sankt-Petersburg, Russia.
Abstract:
The qaim of the research was to evaluate a condition of cellular and humoral immunity in 139 children with bronchiolitis obliterans in age from 2 years to 14 years of life. There was a minor immunosuppression during exacerbation followed by normalization in remission. There was a slight decrease in the level of IgA, an increased concentration of İgM and high value of the circulating immune complexes during the exacerbation with normalization as acute inflammation subsided. An analysis of interleukin dynamics revealed a significant increase in the concentration of pro- and anti-inflammatory cytokines in the acute stage of the disease with a tendency to normalization in remission. Thus, there is no place marked immunosuppression. Analyzed changes are adequate and are a response to viral and bacterial infection.
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