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Rapid Molecular Detection and Differentiation of Influenza Viruses A and B
05:38

Rapid Molecular Detection and Differentiation of Influenza Viruses A and B

Published on: January 30, 2017

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CLINICAL AND EPIDEMIOLOGICAL CHARACTERIZATION OF INFLUENZA A/H1N1PDM AND B AMONG HOSPITALIZED CHILDREN, GEORGIA,

A Machablishvili1, D Tsereteli1, Kh Zakhashvili1

  • 11National Center for Disease Control and Public Health, Tbilisi; 2I. Javakhishvili Tbilisi State University, Georgia.

Georgian Medical News
|June 4, 2017
PubMed

Insights

Influenza A(H1N1)pdm and B in children showed similar clinical features and outcomes post-pandemic. Pre-existing neurological conditions and congenital malformations increased severe influenza risks, highlighting the need for vaccination and prompt antiviral treatment.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • The post-pandemic season saw continued circulation of influenza A(H1N1)pdm and influenza B viruses.
  • Understanding the clinical and epidemiological differences between these strains in hospitalized children is crucial for public health management.

Purpose of the Study:

  • To compare the clinical and epidemiological characteristics of laboratory-confirmed influenza A(H1N1)pdm and B cases in hospitalized children.
  • To identify risk factors associated with severe outcomes and complications.

Main Methods:

  • A retrospective observational study was conducted between January 1 and May 1, 2011.
  • Data were collected from 290 hospitalized children with confirmed influenza A(H1N1)pdm (n=122) or influenza B (n=168).
  • Clinical symptoms, hospital stay duration, intensive care unit (ICU) admission, and pre-existing conditions were analyzed.

Main Results:

  • Influenza A(H1N1)pdm and B cases had similar median ages (2 years) and hospital stays (5 days).
  • Fever, cough, and runny nose were predominant symptoms; lower respiratory tract infections and pneumonia occurred in 39.7% and 19% of patients, respectively.
  • Neurological pre-existing conditions and congenital malformations were significantly associated with increased pneumonia risk and ICU admission.

Conclusions:

  • No significant differences were observed between influenza A(H1N1)pdm and B regarding clinical presentation, hospital stay, or complications in hospitalized children.
  • Pre-existing conditions, particularly neurological disorders and congenital malformations, are key risk factors for severe influenza.
  • Annual influenza vaccination and timely antiviral treatment are recommended to prevent severe outcomes and complications.

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