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DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

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Published on: October 25, 2017

Parallel and antiparallel cyclic d/l peptide nanotubes.

Mitchell R Silk¹, Janet Newman, Julian C Ratcliffe

¹Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. david.chalmers@monash.edu.

Chemical Communications (Cambridge, England)

|June 6, 2017

Summary

This summary is machine-generated.

Researchers determined the first crystal structures of cyclic peptide (CP) nanotubes, revealing antiparallel and parallel stacking arrangements. This structural insight advances nanomaterial development from diverse peptide self-assembly.

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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Area of Science:

Supramolecular chemistry
Nanomaterials science
Structural biology

Background:

Hydrogen-bonded cyclic peptide (CP) nanotubes offer potential for diverse nanomaterials.
Structural characterization challenges have limited the development of these CP nanotubes.

Purpose of the Study:

To present the first crystal structures of continuous cyclic peptide nanotubes.
To elucidate the distinct antiparallel and parallel stacking arrangements in CP nanotubes.

Main Methods:

X-ray crystallography was employed to determine the structures.
Two specific cyclic peptides, cyclo[(Asp-d-Leu-Lys-d-Leu)2] and cyclo[(Asp-d-Ala-Lys-d-Ala)2], were synthesized and assembled into nanotubes.

Main Results:

The first crystal structures of continuous cyclic peptide nanotubes were obtained.
Two distinct stacking arrangements were identified: antiparallel and parallel.
The structures were determined for nanotubes assembled from cyclo[(Asp-d-Leu-Lys-d-Leu)2] and cyclo[(Asp-d-Ala-Lys-d-Ala)2].

Conclusions:

This work provides crucial structural insights into cyclic peptide nanotube assembly.
Understanding these stacking arrangements facilitates the rational design of novel peptide-based nanomaterials.