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Updated: Mar 1, 2026

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
Published on: April 18, 2013
Relative Nephrotoxicity of Different Contrast Media
Iram Aqeel1, Amarinder S Garcha1, Michael R Rudnick1
1Renal, Electrolyte and Hypertension Division, University of Pennsylvania, 3400 Spruce Street, One Founders, Philadelphia, PA 19104, USA.
Abstract:
Contrast-induced nephropathy (CIN) is a common cause of acute kidney injury among hospitalized patients. High-osmolar contrast agents are associated with increased risk of CIN. Low-osmolar (LOCM) and iso-osmolar (IOCM) agents show no difference in the incidence of CIN, even among high-risk patients. This finding suggests that factors other than osmolality may play a role in the pathogenesis of CIN. The use of either LOCM or IOCM agents is recommended in high-risk patients.
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