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Geometrical Effect in 2D Nanopores
Ke Liu, Martina Lihter, Aditya Sarathy
1Department of Engineering, University of Cambridge , JJ Thomson Avenue, CB3 0FA Cambridge, United Kingdom.
Nano Letters
|June 9, 2017
Summary
Researchers explored how nanopore shape affects DNA translocation. They found that non-circular nanopores, like triangular ones, significantly alter ion flow, leading to a geometry-dependent ion scattering effect.
Area of Science:
- Nanotechnology
- Materials Science
- Biophysics
Background:
- Solid-state nanopores lack precise geometric control compared to biological protein nanopores.
- Experimentally formed solid-state nanopores typically exhibit a circular shape.
Purpose of the Study:
- Investigate the impact of nanopore geometry on ion blockage during DNA translocation.
- Compare triangular (h-BN) and circular (MoS2) nanopore shapes.
Main Methods:
- Fabrication and experimentation with triangular and circular solid-state nanopores.
- Measurement of ionic blockage during DNA translocation.
- Development and application of a modified ionic blockage model.
Main Results:
- Observed a significant geometry-dependent ion scattering effect.
- Validated experimental findings with a modified ionic blockage model.
- Demonstrated that pore geometry influences ion permeability and scattering.
Conclusions:
- Nanopore shape critically affects ion scattering and blockage during DNA translocation.
- A modified ionic blockage model accounting for geometric variations improves accuracy.
- Findings guide the rational design of two-dimensional (2D) nanopores for various applications.
