Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The noncoding circular RNA <i>circHomer1</i> regulates synaptic development and experience-dependent plasticity in the mouse visual cortex.

iScience·2025
Same author

CAA-related enlarged perivascular spaces are associated with abnormal angioarchitecture in human brain tissue: A key role for white matter atrophy?

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2025
Same author

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety.

Cell·2025
Same author

Uniform volumetric single-cell processing for organ-scale molecular phenotyping.

Nature biotechnology·2025
Same author

Glioblastoma Cortical Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer.

Cancer discovery·2024
Same author

The noncoding circular RNA <i>circHomer1</i> regulates synaptic development and experience-dependent plasticity in mouse visual cortex.

bioRxiv : the preprint server for biology·2024
Same journal

Erratum for the Research Article "Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer".

Science translational medicine·2026
Same journal

CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis.

Science translational medicine·2026
Same journal

Bioresponsive microneedle stent provides anastomosis and postoperative adjuvant therapy in preclinical resectable intestinal diseases.

Science translational medicine·2026
Same journal

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine·2026
Same journal

KSHV-infected endothelial cells expand and up-regulate angiogenic pathways and CXCR4 in patient-derived Kaposi sarcoma models.

Science translational medicine·2026
Same journal

Hypoxia-driven T cell-macrophage-stromal cross-talk sustains fibrosis in preclinical models of cutaneous chronic graft-versus-host disease.

Science translational medicine·2026
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

Modeling Human Cerebellar Development In Vitro in 2D Structure
06:14

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

2.1K

Modeling human brain development.

Kwanghun Chung1

  • 1Department of Chemical Engineering, Institute for Medical Engineering and Science (IMES), Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Science Translational Medicine
|June 9, 2017
PubMed
Summary
This summary is machine-generated.

Human forebrain spheroids allow scientists to observe how specific brain regions develop and form connections in a lab setting. This model aids in understanding early human brain development and neural circuit formation.

More Related Videos

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

21.6K
Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

22.4K

Related Experiment Videos

Last Updated: Mar 1, 2026

Modeling Human Cerebellar Development In Vitro in 2D Structure
06:14

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

2.1K
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

21.6K
Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

22.4K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Understanding human brain development is crucial for addressing neurological disorders.
  • Current models often lack the complexity to study region-specific developmental processes.
  • In vitro models are needed to investigate early human neural development.

Purpose of the Study:

  • To establish and utilize human forebrain spheroids for studying early brain development.
  • To observe region-specific neural migration patterns in vitro.
  • To investigate the formation of neural circuits within developing human brain organoids.

Main Methods:

  • Generation of human forebrain spheroids from pluripotent stem cells.
  • Longitudinal imaging and analysis of cellular migration and differentiation.
  • Assessment of synaptic marker expression and network activity.

Main Results:

  • Human forebrain spheroids recapitulate key aspects of early cortical development.
  • Distinct region-specific neural migration patterns were observed within the spheroids.
  • Evidence of nascent neural circuit formation and connectivity was detected.

Conclusions:

  • Human forebrain spheroids provide a powerful platform for studying human brain development in vitro.
  • These organoids facilitate the investigation of neural migration and circuit formation.
  • This model holds potential for understanding developmental disorders and testing therapeutics.