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Related Experiment Videos

Experimental rabies in hibernator rodents.

A D Botvinkin, T A Nikiforova, G N Sidorov

    Acta Virologica
    |January 1, 1985
    PubMed
    Summary

    Hibernation significantly extends rabies virus incubation in sousliks, suggesting these animals may be a natural reservoir. This finding aids research into rabies virus persistence mechanisms.

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    Area of Science:

    • Veterinary Virology
    • Wildlife Disease Ecology
    • Mammalian Physiology

    Background:

    • Rabies virus poses a significant threat to public health and animal populations.
    • Understanding viral persistence mechanisms is crucial for disease control.
    • Hibernation's impact on viral incubation periods is not well-established.

    Purpose of the Study:

    • To investigate the effect of hibernation on rabies virus incubation and persistence in sousliks (Citellus major Pall.).
    • To explore the potential of heterothermal rodents as a natural reservoir for rabies virus.
    • To identify potential sites of viral persistence within infected animals.

    Main Methods:

    • Infection of sousliks with different rabies virus strains during active periods and hibernation.
    • Monitoring survival times and calculating mean incubation periods.
    • Virus isolation and detection using fluorescent antibody testing in various tissues, including brown fat.

    Main Results:

    • Hibernation significantly prolonged the incubation period of rabies virus in sousliks (147.3 days vs. 32 days).
    • Rabies virus was detected in brown fat in 50% of cases, and also in salivary glands and visceral organs.
    • Viral detection in brown fat was possible only within 6 days prior to death.

    Conclusions:

    • Heterothermal rodents, like sousliks, exhibit prolonged rabies virus incubation during hibernation.
    • Brown fat may serve as a site for rabies virus persistence.
    • These findings suggest that heterothermal rodents could represent a natural reservoir for rabies virus, warranting further investigation.

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