Related Experiment Video
Updated: Feb 28, 2026

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
Tissue necrosis following extravasation of acyclovir in an adolescent: A case report
Charalambos Neocleous1, Eleni Andonopoulou2, Alkistis Adramerina2
1Department of Medical Pediatrics, Thriasio General Hospital, Athens, Greece. xneoc@yahoo.gr.
Objective:
Extravasation of intravenously infused vesicant solutions is a common problem in medical practice, which can lead to severe and progressive tissue dysfunction, ranging from persistent tissue oedema and fibrosis to delayed tissue necrosis. Acyclovir is a known vesicant medication administrated in paediatric patients, which appears to irritate venous and soft tissue if extravasated.
Case Report:
We present the first case involving the extravasation of intravenously infused acyclovir in a female adolescent patient, which caused tissue necrosis and left behind a residual scar lesion. Nursing and medical staff should be aware of the potential dermatological side effects of intravenously infused acyclovir and other medications, even a long time after infusion, and the possible lack of initial local symptoms and signs.
Conclusion:
Early recognition of extravasation and prompt management are critical in preventing further morbidity, and optimizing outcomes.
Related Concept Videos
Acute Kidney Injury I: Introduction
Acute Pyelonephritis I: Introduction
Acute Kidney Injury III: Clinical Manifestations
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury IV: Diagnostic Studies and Prevention

