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Milk basic protein increases ghrelin secretion and bone mineral density in rodents
Yuko Ishida1, Rakhi Chacrabati2, Aiko Ono-Ohmachi3
1Milk Science Research Institute, Megmilk Snow Brand Co., Ltd., Kawagoe, Saitama, Japan.
Nutrition (Burbank, Los Angeles County, Calif.)
|June 14, 2017
Summary
Milk basic protein (MBP) increases bone mineral density by stimulating ghrelin secretion. This study suggests MBP directly enhances ghrelin release, which may mediate bone formation.
Area of Science:
- Biochemistry
- Endocrinology
- Bone Biology
Background:
- Milk basic protein (MBP) is known to promote bone formation.
- Ghrelin, a peptide hormone, also stimulates osteoblast formation.
- The potential link between MBP and ghrelin in bone metabolism is unexplored.
Purpose of the Study:
- To investigate if MBP-induced bone formation is mediated by ghrelin.
- To determine the direct effect of MBP on ghrelin secretion.
Main Methods:
- Chronic administration of MBP to mice and measurement of bone mineral density and plasma ghrelin levels.
- In vitro studies using gastric tissue and mucosal cells to assess MBP's effect on ghrelin release.
- Enzyme-linked immunosorbent assay (ELISA) for quantifying plasma biomarkers.
Main Results:
- MBP intake increased plasma ghrelin concentration and bone mineral density in mice.
- MBP dose-dependently stimulated ghrelin release from gastric tissues and cells in vitro.
- Adrenergic blockers partially inhibited MBP-induced ghrelin secretion.
Conclusions:
- MBP directly stimulates ghrelin secretion through a mechanism partly involving adrenergic pathways.
- Elevated ghrelin levels induced by MBP may serve as a mediator for enhanced bone formation.
- This study elucidates a novel pathway linking dietary protein to bone metabolism via ghrelin.
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