Related Experiment Video
Updated: Feb 28, 2026

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat VNTR - Fragment Length Analysis FLA
Published on: July 15, 2011
Strain-based HLA association analysis identified HLA-DRB1*09:01 associated with modern strain tuberculosis
L Toyo-Oka1,2, S Mahasirimongkol1, H Yanai3,4
1Medical Genetics Center, Medical Life Science Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Human leukocyte antigen (HLA) class II genes are linked to susceptibility to Tuberculosis (TB) caused by modern Mycobacterium tuberculosis strains. This highlights the need for strain-specific genetic analysis in TB research.
Area of Science:
- Immunogenetics
- Microbiology
- Population Genetics
Background:
- Tuberculosis (TB) results from host-pathogen interactions, with Human Leukocyte Antigen (HLA) class II molecules crucial for immune response.
- Previous research has not explored the link between specific HLA class II genes and susceptibility to TB strains.
Purpose of the Study:
- To investigate the association between HLA class II genes and susceptibility to TB caused by modern and ancient Mycobacterium tuberculosis (MTB) strains.
- To determine if specific HLA class II alleles and haplotypes correlate with TB susceptibility in relation to MTB strain type.
Main Methods:
- Genotyping of HLA-DRB1 and HLA-DQB1 alleles in 682 TB patients and 836 controls.
- Classification of MTB strains using large sequence polymorphism typing.
- Association analysis of common HLA alleles and haplotypes with TB susceptibility across different MTB strains.
Main Results:
- Significant associations were found between HLA-DRB1*09:01 (OR=1.82) and HLA-DQB1*03:03 (OR=1.76) alleles and susceptibility to TB caused by modern MTB strains.
- Haplotype analysis indicated strong linkage disequilibrium between these associated alleles, without evidence of interactive effects.
- No significant associations were observed for ancient MTB strains.
Conclusions:
- HLA class II genes, specifically HLA-DRB1*09:01 and HLA-DQB1*03:03, are associated with susceptibility to TB caused by modern MTB strains.
- The findings underscore the importance of considering Mycobacterium tuberculosis strain diversity in genetic susceptibility studies for TB.
- Strain-specific genetic analyses are crucial for identifying host genes that influence TB susceptibility.
More Related Videos
08:03Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
10:37Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Related Concept Videos
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Modern Molecular Taxonomy
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...