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Updated: Feb 28, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
A double - blind randomised multicentre controlled study of topical 0.05% clobetasol propionate with 2.5% zinc
Jayakar Thomas1, Sanjiv Kandhari2, Chetan Oberoi3
1Department of Dermatology, Thanjavur Medical College, Thanjavur 613004, India.
Abstract:
The aim of this study was to compre the efficacy and safety of topical clobetasol propionate and clobetasol propionate with zinc sulphate cream preparation. Steroid responsive dermatoses were primarily considered in both the treatment groups. From thc analysis of 291 patients, from five different centres, it wasnoted that though the out come was Positive in both the trial groups significant differences existed in the treatment group which received clobetasol propionate with zinc sulphate preparation. During evaluation the outcome was even between both treatment groups on the day 7. However towards the end of the study significant differences existed. Interestingly both the treatment groups did not have any adverse effects.
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