Related Experiment Video
Updated: Feb 28, 2026

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
Published on: May 24, 2016
Opioid-free anaesthesia in three dogs
Donna M White1, Alastair R Mair1, Fernando Martinez-Taboada1
1Department of Anaesthesia and Analgesia, Veterinary Teaching Hospital, University of Sydney, Evelyn Williams Building B10, 65 Parramatta Road, Camperdown, NSW. 2050. Australia.
Opioid-free anesthesia (OFA) is feasible in veterinary medicine, demonstrated in a case series of dogs undergoing ovariohysterectomy. While challenging, OFA offers an alternative to traditional opioid use in veterinary patients.
Area of Science:
- Veterinary Anesthesiology
- Pain Management
- Comparative Medicine
Background:
- Opioid-free anesthesia (OFA) is an emerging field in human medicine due to concerns about opioid-induced hyperalgesia, tolerance, and immunomodulation.
- Opioids are traditionally central to veterinary anesthesia and pain management.
- Exploring OFA in veterinary patients addresses the need for opioid-sparing strategies.
Observation:
- A case series involving three dogs undergoing ovariohysterectomy under OFA is presented.
- The study details the practical application and challenges of implementing OFA in a clinical veterinary setting.
- Canine ovariohysterectomy served as a standard procedure for evaluating OFA feasibility.
Findings:
- Opioid-free anesthesia is achievable in veterinary patients.
- Transitioning from traditional opioid-based protocols presents challenges for veterinary anesthesiologists.
- Successful implementation requires gaining experience with OFA protocols for routine procedures.
Implications:
- This study supports the potential for OFA in veterinary medicine, offering an alternative to conventional opioid use.
- Developing OFA protocols for common surgeries like neutering can build confidence for more complex procedures.
- Further research and experience with OFA can advance pain management and anesthesia practices in animals, potentially reducing opioid-related adverse effects.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Parenteral Anesthetics: Overview
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Opioid Analgesics: Morphine and Other Natural Cogeners

