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On-a-chip Biosensing Based on All-Dielectric Nanoresonators.

Ozlem Yavas1, Mikael Svedendahl1, Paulina Dobosz1

  • 1ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology , 08860 Castelldefels (Barcelona), Spain.

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Summary

Silicon nanoresonators in microfluidics offer a promising alternative to gold nanoparticles for biosensing. This new lab-on-a-chip technology enables sensitive detection of cancer markers in serum for personalized healthcare.

Keywords:
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Area of Science:

  • Biomedical engineering
  • Nanophotonics
  • Biosensing

Background:

  • Nanophotonics, particularly plasmonic nanoparticles, is crucial for early disease diagnosis and less invasive therapies.
  • Plasmonic nanoparticles concentrate light for biosensing and enhanced spectroscopy.
  • High-refractive index dielectric nanostructures offer a potential alternative to nanoplasmonics, with improved sensing and microelectronics compatibility.

Purpose of the Study:

  • To demonstrate biosensing using silicon nanoresonators integrated into microfluidics.
  • To compare the sensing performance of silicon nanoresonators with plasmonic gold nanorods.
  • To develop a lab-on-a-chip platform for sensitive cancer marker detection.

Main Methods:

  • Integration of silicon nanoresonators into state-of-the-art microfluidic devices.
  • Detection of Prostate Specific Antigen (PSA) cancer marker in human serum.
  • Comparative analysis of silicon nanoresonator and gold nanorod sensor performance.

Main Results:

  • Successful demonstration of biosensing using silicon nanoresonators in microfluidics.
  • Detection of PSA cancer marker in human serum with clinically relevant sensitivity.
  • Silicon nanoresonators show comparable or superior performance to gold nanorods.

Conclusions:

  • Silicon nanoresonators represent a viable and high-performance alternative to plasmonic nanostructures for biosensing.
  • The developed lab-on-a-chip platform meets clinical sensitivity needs for cancer marker detection.
  • This technology paves the way for advanced point-of-care devices and personalized healthcare solutions.