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Ribbon thickness influences fine generation during dry granulation.

Wei-Jhe Sun1, Changquan Calvin Sun1

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Controlling ribbon thickness during roller compaction is key to reducing fine particles in dry granulation. This finding helps develop a robust process for successful manufacturing scale-up.

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Area of Science:

  • Pharmaceutical Sciences
  • Chemical Engineering
  • Materials Science

Background:

  • Dry granulation using roller compaction is a common pharmaceutical manufacturing technique.
  • Generation of fine particles during milling is a significant challenge affecting process robustness.

Purpose of the Study:

  • To investigate the impact of process parameters on fine generation during roller compaction.
  • To identify critical parameters for controlling fine particle formation in dry granulation.

Main Methods:

  • Roller compaction experiments were conducted.
  • Ribbon thickness was systematically varied and analyzed.
  • Percentage of fines was quantified.

Main Results:

  • A significant correlation was observed between ribbon thickness and the percentage of fines generated.
  • Thinner ribbons resulted in a higher percentage of fines.

Conclusions:

  • Ribbon thickness is a critical parameter that must be controlled during roller compaction.
  • Controlling ribbon thickness is essential for developing a robust dry granulation process and ensuring successful scale-up.