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Role of ESCRT component HD-PTP/PTPN23 in cancer

Marie-Claude Gingras1,2, Jalal M Kazan1,2, Arnim Pause3,2

  • 1Department of Biochemistry, McGill University, Montréal, Québec, Canada H3G 1Y6.

Biochemical Society Transactions
|June 17, 2017
PubMed

Insights

Endosomal Sorting Complexes Required for Transport (ESCRT) components regulate cell signaling to prevent cancer. The ESCRT member HD-PTP/PTPN23 acts as a tumor suppressor, highlighting ESCRT

Area of Science:

  • Cellular Biology
  • Molecular Oncology
  • Biochemistry

Background:

  • Sustained cell signaling from plasma membrane receptors is linked to cancer.
  • Endosomal sorting and degradation of cell surface receptors are vital for preventing chronic signaling and tumorigenesis.
  • The Endosomal Sorting Complexes Required for Transport (ESCRT) machinery controls these receptor trafficking processes.

Purpose of the Study:

  • To review the role of ESCRT components in cancer.
  • To summarize the functions of HD-PTP/PTPN23 in tumorigenesis.
  • To clarify the bona fide role of ESCRT components in cancer development.

Main Methods:

  • Literature review of ESCRT function in cancer.
  • Analysis of studies on HD-PTP/PTPN23 in vitro and in vivo.
  • Summary of evidence for ESCRT components as tumor suppressors.

Main Results:

  • ESCRT components are proposed tumor suppressors due to their role in receptor regulation.
  • HD-PTP/PTPN23 is identified as a novel haplo-insufficient tumor suppressor.
  • Evidence supports the involvement of ESCRT in preventing chronic signaling and tumorigenesis.

Conclusions:

  • ESCRT machinery plays a critical role in regulating cell surface receptors and preventing cancer.
  • HD-PTP/PTPN23 functions as a tumor suppressor, underscoring the importance of ESCRT in cancer prevention.
  • Further research into ESCRT components can reveal new therapeutic strategies for cancer.
Keywords:
ESCRTHD-PTPPTPN23tumour suppressor

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