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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer

Dae-Hee Lee1,2, Suk-Young Lee2, Sang Cheul Oh1,2

  • 11 Division of Brain Korea 21 Program for Biomedicine Science, College of Medicine, Korea University, Seoul, Republic of Korea.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|June 17, 2017
PubMed

Insights

The sonic hedgehog (SHH) signaling pathway is crucial for development but linked to cancers. This review explores SHH

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Oncology

Background:

  • The sonic hedgehog (SHH) signaling pathway regulates critical developmental processes.
  • Aberrant SHH pathway activation is implicated in various human cancers.
  • Targeted molecular therapies for SHH in gastric cancer are currently lacking.

Purpose of the Study:

  • To review current treatments for advanced gastric cancer.
  • To discuss the role of the SHH signaling pathway in gastric cancer.
  • To explore molecular crosstalk involving SHH in cancer stem cells.

Main Methods:

  • Literature review of clinical treatments for advanced gastric cancer.
  • Analysis of the SHH signaling pathway's function in embryogenesis and cancer.
  • Review of studies on SHH pathway crosstalk in cancer stem cells.

Main Results:

  • Advanced gastric cancer treatment options are limited.
  • The SHH pathway plays a significant role in gastric cancer progression.
  • Interactions between SHH and other pathways in cancer stem cells are being identified.

Conclusions:

  • There is a need for targeted molecular therapies for SHH in gastric cancer.
  • Understanding SHH pathway crosstalk is vital for developing novel cancer treatments.
  • Further research into SHH signaling could lead to improved therapeutic strategies for advanced gastric cancer.
Keywords:
Advanced gastric cancercancer stem cellschemotherapysonic hedgehogtarget therapy

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