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Continuous intrathecal baclofen for severe spasticity.

R D Penn, J S Kroin

    Lancet (London, England)
    |July 20, 1985
    PubMed
    Summary
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    Intraspinal baclofen delivered via programmable pumps significantly reduced muscle rigidity and spasms in spinal cord injury patients. This targeted delivery minimized side effects, improving patient comfort and daily function.

    Area of Science:

    • Neurology
    • Pharmacology
    • Biomedical Engineering

    Background:

    • Baclofen is a primary treatment for spinal cord injury-induced rigidity and spasms.
    • Current oral administration often provides limited relief and is constrained by central side effects.

    Purpose of the Study:

    • To evaluate the efficacy of intraspinal baclofen delivery using implantable programmable pumps.
    • To assess improvements in muscle tone, spasms, patient comfort, and daily activities.

    Main Methods:

    • Six patients with spinal cord injury received intraspinal baclofen via lumbar subarachnoid pumps.
    • Doses ranged from 12 to 400 micrograms per day, with treatment duration up to 7 months.

    Main Results:

    • Intraspinal baclofen led to immediate normalization of muscle tone.

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  • Complete elimination of spontaneous spasms was observed.
  • Patients reported reduced discomfort and enhanced ability to perform daily activities.

    • Conclusions:

    • Implantable programmable pumps enable efficient intraspinal baclofen delivery for spinal cord injury.
    • This method effectively manages rigidity and spasms while mitigating central side effects.