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Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

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Surface Modification of PDMS and Plastics with Zwitterionic Polymers.

Mutsuo Tanaka¹, Shigeru Kurosawa¹

¹Health Research Institute, Advanced Industrial Science and Technology (AIST).

Journal of Oleo Science

|June 20, 2017

Summary

Zwitterionic polymers enhance surface hydrophilicity and reduce protein adsorption on PDMS, polycarbonate, and acrylic resin. This surface modification offers stable, long-lasting biocompatibility for various materials.

Keywords:

PDMS hydrophilicity polymer surface modification

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Area of Science:

Materials Science
Polymer Chemistry
Surface Chemistry

Background:

Biomaterial surface properties significantly influence biological interactions.
Polydimethylsiloxane (PDMS), polycarbonate, and acrylic resin are widely used in biomedical applications.
Nonspecific protein adsorption is a major challenge in biomaterial development.

Purpose of the Study:

To investigate the surface modification of PDMS, polycarbonate, and acrylic resin using methacryl polymers.
To evaluate the stability and hydrophilicity of modified surfaces.
To assess the effectiveness of these modifications in suppressing nonspecific protein adsorption.

Main Methods:

Surface modification of PDMS, polycarbonate, and acrylic resin using plasma treatment.
Grafting of methacryl polymers containing sulfobetaine, phosphoryl choline, and oligoethylene glycol units.
Evaluation of surface hydrophilicity using contact angle measurements.
Assessment of bovine serum albumin (BSA) adsorption using ellipsometry or similar techniques.

Main Results:

Zwitterionic polymers adsorbed effectively onto plasma-treated PDMS surfaces.
Modified PDMS surfaces maintained high hydrophilicity for at least one month.
Specific sulfobetaine polymers demonstrated unique adsorption on plasma-treated polycarbonate.
All modified surfaces exhibited a significant reduction in nonspecific BSA adsorption compared to plasma-treated controls.

Conclusions:

Surface modification with zwitterionic polymers offers a stable and effective method to enhance biomaterial properties.
These modifications improve hydrophilicity and reduce protein fouling, crucial for biomedical applications.
The developed polymer grafting techniques provide a versatile approach for tailoring surface characteristics of common biomaterials.