Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proton Transfer Shuttle Mediated Dormant-Active Balance for Accelerated and Controlled Polymerization of N-Carboxyanhydrides.

Angewandte Chemie (International ed. in English)·2026
Same author

Light-programmable, high-drug-loading nanomedicine based on dimeric camptothecin.

Biomaterials science·2026
Same author

Harnessing Self-Assembling Peptides on γδ T Cells to Enhance Anti-Tumor Immunity.

Polymer science & technology (Washington, D.C.)·2026
Same author

Exploring the polymorphism of foxtail millet proteins and the mechanisms of activity variations driven by varietal differences.

Food research international (Ottawa, Ont.)·2026
Same author

Mitofusin-Decorated Extracellular Vesicles Enable Targeted Nucleic Acid Delivery to Mitochondria.

Nano letters·2026
Same author

Insight into the quality and structural mechanism of wheat noodle fortified with broken rice flour.

Food research international (Ottawa, Ont.)·2026
Same journal

Ordered Polar Topological Domains Enabling Giant Second-Harmonic Generation in Ferroelectric Nematic Liquid Crystals.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Dual-Functional Alumina Additive Enabling Efficient, Volumetric Mechanoluminescence for Nighttime Safety Footwear.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Phase Transformation Accompanied by Evolution of Internal Stress and the Coupling Mechanism of Chemical-Mechanical Degradation in Single-Crystal NiRich Cathodes.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Zwitterionic Polymer Electrolytes With Dipole-Rotation-Assisted Ion Conduction for Solid Lithium Metal Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

3D-Printed Ultra-Thin Solid Polymer Electrolytes with Superior Dielectric Properties for Wide Temperature Range All-Solid-State Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Electrostatic Potential Tuning by Low-Volatility Halogenated Additive: Boosting PTQ10-Based Binary OPV to Near 20% Efficiency with High Scalability.

Advanced materials (Deerfield Beach, Fla.)·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.6K

Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors.

Jinjin Chen1,2, Jianxun Ding1, Yucai Wang3

  • 1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|June 21, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces novel dual-transformable nanoparticles (SNPs) that shrink and change charge in acidic tumor environments. This nanomedicine design enhances tumor penetration and drug delivery, leading to significant antitumor effects.

Keywords:
cancer therapycharge reversalnanomedicinesequential responsivenesssize reduction

More Related Videos

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

8.3K
Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging
08:04

Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging

Published on: June 21, 2011

18.9K

Related Experiment Videos

Last Updated: Feb 28, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.6K
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

8.3K
Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging
08:04

Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging

Published on: June 21, 2011

18.9K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Effective nanomedicine requires overcoming biological barriers for enhanced drug delivery.
  • Current nanomedicine designs struggle with achieving both prolonged circulation and deep tumor penetration.
  • Developing nanomedicine with transformable size and surface charge is crucial for improved therapeutic outcomes.

Purpose of the Study:

  • To design and evaluate a novel shell-stacked nanoparticle (SNP) capable of dual size and charge transformation for enhanced tumor penetration and cellular uptake.
  • To investigate the in vivo performance of SNPs in a xenografted lung carcinoma model.
  • To assess the therapeutic efficacy of doxorubicin-loaded SNPs (SNP/DOX) against solid tumors.

Main Methods:

  • Fabrication of shell-stacked nanoparticles (SNPs) with disulfide-cross-linked cores.
  • Characterization of SNP size and surface charge transformation in response to acidic pH.
  • Evaluation of SNP penetration depth in A549 lung carcinoma xenografts.
  • Assessment of cellular uptake and intracellular drug release mechanisms.
  • In vivo antitumor efficacy studies using SNP/DOX in tumor-bearing mice.

Main Results:

  • SNPs demonstrated remarkable size reduction from ~145 nm to 40 nm and surface charge reversal from -7.4 mV to +8.2 mV in acidic tumor tissue.
  • SNPs achieved approximately 1 mm penetration depth in xenografted A549 lung carcinoma, four times greater than non-transformable nanoparticles.
  • SNP/DOX exhibited significant antitumor efficacy, nearly eradicating tumors, attributed to enhanced penetration and intracellular drug release.

Conclusions:

  • The design of size and charge dual-transformable nanomedicine is critical for overcoming tumor tissue barriers.
  • Shell-stacked nanoparticles (SNPs) offer a promising platform for enhanced tumor penetration, cellular uptake, and therapeutic efficacy.
  • This nanomedicine strategy holds potential for improving cancer treatment by enabling deeper drug delivery into solid tumors.