Controlled release from aspirin based linear biodegradable poly(anhydride esters) for anti-inflammatory activity

Area of Science:

• Polymer Chemistry
• Biomaterials Science
• Drug Delivery Systems

Background:

• Conventional drug delivery systems often face challenges with high drug loading and diffusion-based release mechanisms.
• Incorporating bioactive molecules directly into a polymer backbone presents significant hurdles for achieving substantial drug content.

Purpose of the Study:

• To synthesize a novel linear poly(anhydride ester) for high-capacity, controlled aspirin delivery.
• To investigate the mechanistic insights into aspirin release from the polymer matrix for anti-inflammatory activity.
• To evaluate the cytocompatibility and anti-inflammatory potential of the developed drug-loaded polymer.

Main Methods:

• Synthesis of a linear poly(anhydride ester) utilizing xylitol as a core for aspirin attachment.
• Polymerization of terminal hydroxyl groups with a diacid anhydride.
• Assessment of aspirin release kinetics under physiological conditions.
• Evaluation of polymer cytocompatibility and anti-inflammatory properties in vitro.

Main Results:

• Achieved high aspirin loading of 53% within the poly(anhydride ester) backbone.
• Demonstrated controlled release kinetics, releasing 8.5% and 20% of the drug over one and four weeks, respectively.
• Exhibited good cytocompatibility and significant anti-inflammatory properties, with a release rate constant of 0.0035h^-0.61.

Conclusions:

• The novel aspirin-loaded poly(anhydride ester) offers a promising platform for controlled drug delivery with high loading capacity.
• The polymer's controlled release profile and demonstrated anti-inflammatory activity suggest potential for injectable or implantable bioactive materials.
• Understanding the release mechanism provides a foundation for developing other advanced drug-loaded polymer systems.